This project has been financially supported by the European Union by means of the European Regional Development Fund.
Amount granted: €907,736.52
Innate Pharma has developed an innovative bispecific antibody technology and used it to create novel molecular formats for engaging NK cells to kill tumor cells through NKp46.
NKp46 is an activating receptor expressed on all natural killer cells. It is the most specific marker of human NK cells and plays a major role in their tumor cell recognition. NKp46-bispecific NK cell engagers bind with one arm to an antigen at the surface of tumor cells, and with another arm to the NKp46 receptor on NK cells. This leads to activation and specific tumor-killing by NK cells.
Innate Pharma’s novel type of bispecific antibodies specifically triggers NK cells instead of T cells, which may reduce the risk of the side-effects associated with T cell engagers.
This technology offers opportunities to expand Innate Pharma’s in-house pipeline of drug candidates and partnering.
Laurent Gauthier et al, 2019. Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity Cell Mittal et al, 2018. Overcoming Acquired PD-1/PD-L1 Resistance with CD38 Blockade Cancer Discov. Cerwenka et al, 2018. Natural killers join the fight against cancer Science Chiossone et al, 2018. Natural killer cells and other innate lymphoid cells in cancer Nat Rev Immunol. Mamessier et al, 2011. Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity The Journal of clinical investigation Bryceson et al, 2009. Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors Blood