IPH6401, NK-cell engager

What is IPH6401/SAR445514?

IPH6401/SAR445514 (SAR’514) is a trifunctional anti-BCMA NKp46/CD16 NK cell engager using Sanofi’s proprietary CROSSODILE® multi-functional platform, which comprises the Cross-Over-Dual-Variable-Domain (CODV) format.

Mechanism of action

It induces a dual targeting of the NK activating receptors, NKp46 and CD16, for an optimized NK cell activation, based on Innate’s ANKET® (Antibody-based NK cell Engager Therapeutics) proprietary platform. 

 

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